Mtmr8 knockdown results in vascular defects. (A-D) Vascular morphology in Cont-MO (A), mtmr8-MO (B), mtmr8-MO+ mtmr8 mRNA (C) and mtmr8-MO+dnPKA mRNA Tg(kdrl:GFP)la116 embryos at 48 hpf. The presumptive lumen of DA and PCV are indicated by red and white bars, respectively. White arrowheads point to the interruption of Se. (E, F) Longitudinal sections of trunk regions in 48 hpf corresponding embryos. (G-I) Transverse sections of trunk regions in 48 hpf corresponding embryos. Sections were stained with hematoxylin and eosin. (J) Statistical data of three different defects in three independent experiments of Cont-MO, mtmr8-MO, mtmr8-MO+mtmr8 mRNA, mtmr8-MO+mis-mtmr8 mRNA, mtmr8-MO+dnPKA mRNA, and mtmr8-MO+scl mRNA.