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Figure 3 | BMC Developmental Biology

Figure 3

From: Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient

Figure 3

RA-induced differentiation causes sharper decreases in Oct4 mRNA levels. Xist and Oct4 RNA levels in wild-type and Tsix-mutant male ES cells under various differentiation conditions. Error bars represent one standard deviation from the mean. Days of differentiation are listed as day 0 (d0), day 2 (d2), day 4 (d4), and day 6 (d6). Pairwise comparisons were made between corresponding samples at each differentiation time point for EB vs. EB+RA (red asterisks) and TC vs. TC+RA (green asterisks). * P < 0.05. Statistical significance was calculated using paired, two-tailed Student's t-tests.

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