Figure 1

Summary of Xist phenotypes in Tsix -mutant male ES cell lines. All mutant ES cell lines are XY diploid male (except where noted) and listed with the names used in the original references. XY Tg, male transgenic line; shaded rectangle represents the 37-kb region re-inserted into a deleted locus; •••, extends beyond the Xic diagram depicted; RA, retinoic acid. SA/tpA, please refer to cited references for details. The 'yes/no' designation for pAA2Δ1.7 refers to the very low number of Xist-positive cells and the fact that there is no excessive cell death or inviability reported in these cells or mice. Differentiation in the presence (+) or absence (-) of retinoic acid is indicated.