Figure 7
A model on the role of Reck in vascular remodeling. In the presence of Reck, an immature vascular plexus (A) can be remodeled into a hierarchically branched system (B). Lack of Reck results in abnormally large vessels or blood-filled cavities in the tissues (C), which may result from reduced bifurcation or excessive vascular fusion. Some of the Reck-positive cells (blue in D) may participate in vascular remodeling via non-sprouting mechanisms, such as intussusception and pruning.