Figure 6
From: Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system
In vivo MRI investigation of parenchymal brain abnormalities in Mpl-/-mice. Four Mpl-/- mice were analysed in vivo in two developmental stages (neonatal (P7) and adult) using a standardised high resolution MRI protocol comprising triplanar T2- and T2*-weighted MRI. The cortex as well as the periventricular area including the subventricular zone (SVZ) can be most adequately appreciated in axial slice directions (panel A); the thalami and the hippocampi in coronal slice directions (panel B); the cerebellum and the medulla oblongata in sagittal slice directions (panel C). The brain parenchyma of neither neonatal nor adult Mpl-/- mice presented with any gross abnormalities concerning morphology, volume or signal alterations compared to healthy wild type mice.