Figure 2
From: Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system
Detection of Mpl-positive cells in the embryonic central nervous system. Schematic drawings show the positions of the micrographs. During early embryonic development both brain and spinal cord are devoid of Mpl labelling. Left column shows representative examples at E12 (A) and E15 (B, C). The green labelling on the blood vessels is unspecific as it also labels negative control sections incubated without the primary antibody. By embryonic day 18 (E18) numerous Mpl-positive cells appear in the inner cortical plate, subventricular zone of the fourth ventricle and parenchymal regions of rhombencephalon (D-G). At P0 the number of Mpl positive cells reaches its peak, spreading throughout many brain regions (I, J, K), including the subventricular zone of the lateral ventricles (H). Dorsal is up, anterior to the left. chp - choroid plexus; cp - cortical plate; dcn - dorsal cochlear nucleus; h - hippocampus; svz - subventriclar zone; wm - white matter; IV - forth ventricle. Scale bar 50 μm.