Skip to main content
Figure 2 | BMC Developmental Biology

Figure 2

From: Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature

Figure 2

Overexpression of Prox1 results in embryonic lethality at E13.5. Control and DT embryos were analyzed at (A and B) E10.5 and (C and D) E12.5. Interestingly, overexpression of Prox1 results in a small amount of hemorrhaging and growth retardation (B; arrowheads). Later time points display exacerbated bleeding with a consistent delay in growth (C and D). (E and F) Histological analysis at E13.5, embryos display gross edema typified by separation of the dermis from the epidermis (F; double arrow). Also significant is the increase in lymph sac size (LS) in Prox1 transgenic embryos. LS: Lymph sac. Orientation arrows for E and F: D- Dorsal, L- Lateral. Scale bars for A and B: 5.0 mm; C and D: 1.0 cm; E: 250 μm and F: 500 μm.

Back to article page