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Figure 1 | BMC Developmental Biology

Figure 1

From: Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature

Figure 1

Bigenic model for Prox1 overexpression. (A) The prox1:tetOS transgene is driven by the tissue specific tie1:tTA promoter. Open circle: tTA, closed circle: Prox1 protein. (B) The expression of Prox1 in E10.5 embryos displays a polarized expression pattern specifically from the cardinal vein. (C) In contrast, overexpression of Prox1 in the double transgenic (DT) embryos display an increase in Prox1 positive cells from the cardinal vein. Significantly, Prox1 is also present on the dorsal aorta, which is normally negative for Prox1 expression. Orientation arrows for B and C: D- Dorsal, L- Lateral. Scale bar: 50 μm.

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