Table 1 Heart weights (HW), body weights (BW), cardiac function, plasma creatine content and creatine uptake during development in the rat heart

HW (g)

0.039 ± 0.01^a

0.13 ± 0.01^b

0.17 ± 0.06^bc

0.24 ± 0.03^c

0.44 ± 0.04^d

0.70 ± 0.07^e

1.17 ± 0.02^f

p < 0.001

[4]

[4]

[7]

[5]

[8]

[6]

[8]

BW (g)

3.59 ± 0.34^a

22.0 ± 1.78^b

35.6 ± 7.08^c

41.5 ± 4.1^c

78.6 ± 2.4^d

178 ± 8.6^e

296 ± 5.3^f

p < 0.001

[4]

[4]

[7]

[5]

[8]

[6]

[8]

HW/BW *1000

10.9 ± 2.1^a

5.79 ± 0.80^ab

4.81 ± 1.15^ab

5.84 ± 0.70^a

5.58 ± 0.47^a

3.93 ± 0.32^b

b 3.94 ± 0.10^b

p < 0.001

[4]

[4]

[7]

[5]

[5]

[6]

[8]

HR (bpm)

-

-

321 ± 5.7

248 ± 4.9

348 ± 5.6

318 ± 34

307 ± 45

NS

[4]

[4]

[4]

[4]

[4]

LDVP (mm Hg)

-

-

69 ± 12.7

88.6 ± 0.36

65.7 ± 7.2

75.7 ± 10.2

97.1 ± 27.6

NS

[4]

[4]

[4]

[4]

[4]

RPP (mm Hg/bpm)

-

-

22129 ± 3673

22047 ± 555

22879 ± 2874

24189 ± 5524

29673 ± 8913

NS

[4]

[4]

[4]

[4]

[4]

Creatine uptake

-

-

3.03 ± 0.55^a

3.66 ± 0.79^ab

3.85 ± 0.62^abc

4.68 ± 0.54^bc

4.99 ± 0.52^c

p < 0.001

(nmol/min/g w.w)

[6]

[5]

[5]

[5]

[6]

Plasma creatine

-

0.971 ± 0.07^a

0.669 ± 0.16^ab

0.678 ± 0.19^ac

0.627 ± 0.12^bc

0.558 ± 0.06^bc

0.536 ± 0.08^bc

p = 0.002

(mmol/L)

[4]

[4]

[4]

[4]

[4]

[4]