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Figure 7 | BMC Developmental Biology

Figure 7

From: Disruption of zebrafish cyclin G-associated kinase (GAK) function impairs the expression of Notch-dependent genes during neurogenesis and causes defects in neuronal development

Figure 7

Cell degeneration phenotype of GAK morphant embryos during development. (A, E) Lateral and (B, F) dorsal views of (A, B) uninjected and (E, F) GAK morphant embryos at 14-somite stage. Visible degeneration in the eyes (E) and the forebrain regions (F) of GAK morphants is indicated by white arrowheads. (C, G) Lateral and (D, H) dorsal views of (C, D) uninjected and (G, H) GAK morphant embryos at 24 hpf. At this stage, the increased cell degeneration within the brain (arrowheads) and thinner yolk extension in GAK morphants is apparent. (I-L) Lateral views of (I, J) uninjected and (K, L) GAK morphant embryos at 36 hpf. In all the lateral views, anterior is to the left and dorsal is up. ey, eye; Hb, hindbrain; nt, neural tube; no, notochord; ov, otic vesicles; ye, yolk extension. Scale Bar, 100 μm.

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BMC Developmental Biology

ISSN: 1471-213X

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