Figure 1
Effects of Dicer1 ablation on adrenal development. Adrenal glands from control (CT) or Sf1/Cre;Dicer1loxP/loxP (KO) embryos (16.5 and 18.5 dpc), newborns (P0), and Day 5 neonates (P5) were collected for (A) gross morphological analysis, (B) immunofluorescence for SF1 (magenta), TH (green), and DAPI (blue), and (C) immunofluorescence for Ki-67 (green), HSD3b (magenta), and DAPI (blue). Higher magnification (2× of the original figure) of the proliferating cells is shown in the inlets. Arrow = adrenal; kd = kidney. Scale bars represent 250 μm.