Figure 2

An interaction network of the melanotic suppressors. The 59 confirmed melanotic suppressors identified in the screen are depicted as grey nodes together with their (inferred) name. Additional factors not identified in the screen but linking two or more melanotic suppressors are represented as white nodes. Factors previously associated with melanotic mass development and/or lamellocyte differentiation are underlined. Candidates that were confirmed using non-overlapping dsRNA are indicated in bold. The different melanotic suppressors are grouped in 9 categories (dashed lines) based on GO annotation and data mining. Factors belonging to a well-defined molecular complex are boxed together. Physical or functional interactions between the different factors are represented by edges.