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Figure 1 | BMC Developmental Biology

Figure 1

From: Identification of the heart as the critical site of adenosine mediated embryo protection

Figure 1

Cardiac specific knockout of A1AR reduces embryonic viability under hypoxic conditions. Pregnant dams were reared in room air or hypoxia (10% O2) for 2, 3, or 4 days beginning at E8.5. (A) 2-day treatment from E8.5-10.5, no difference in viability between normoxia and hypoxia, P > 0.05. (B) 3-day treatment from E8.5-11.5, hypoxia induced a decrease in viability of 52% in the A1AR cardiac-specific knockout mice but not in the normal A1AR expressing (Hypoxia +/+) litters. (C) 4-day treatment from E8.5-12.5, hypoxia caused a greater reduction in viability of 78% compared to normoxia controls. In addition, 2-day treatment from E10.5-12.5 induced a significant decrease in viability of 40% that was not seen in the younger 2-day treated (E8.5-10.5) embryos. *, P ≤ 0.05 by Mann-Whitney test with a 99% confidence level.

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