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Table 4 Pharyngeal M2 neuron defects in ten-1 mutants.

From: C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants

Genotype

wt (%)

Misplac (%)

Ipsil (%)

Trunc (%)

Other (%)

N

etIs2

99.8

 

0.2

  

419

mnm-5(et5); etIs2

87.7

8.3

3.9

0.2

 

432

ten-1(ok641); etIs2

86.9

8.5

3.3

1.3

 

459

ten-1(tm651); etIs1

83.3

14.6

2.0

  

246

mig-14;etIs2

85.5

0.9

0.4

3.0

10.3

234

mig-14;etIs2 ok641

36.4

26.6

8.9

12.1

15.9

214

sax-3; etIs2

68.9

5.1

7.2

2.9

15.7

235

sax-3; etIs2 ok641

LETHAL

    

-

slt-1; etIs2

97.3

 

1.9

0.8

 

262

slt-1; etIs2 ok641

93.9

1.1

3.0

1.9

 

264

unc-5; etIs2

76.8

 

16.0

7.2

 

250

unc-5; etIs2 ok641

35.6

6.2

42.9

15.3

 

177

unc-6; etIs2

23.7

0.4

37.9

37.9

 

253

unc-6; etIs2 ok641

42.2

6.6

42.2

8.3

0.6

469

unc-34; etIs2

91.8

 

4.9

3.3

 

245

unc-34; etIs2 ok641

LETHAL

    

-

unc-40; etIs2

78.3

 

6.5

14.8

0.4

230

unc-40; etIs2 ok641

78.6

2.5

10.7

8.2

 

280

unc-51; etIs2

83.7

 

5.9

10.4

 

270

unc-51; etIs2 ok641

49.2

7.4

33.5

9.7

 

268

unc-52; etIs2

94.4

 

3.7

1.8

 

215

unc-52; etIs2 ok641

40.8

7.1

42.9

9.2

 

184

unc-73; etIs2

50.4

 

19.9

29.7

 

236

unc-73; etIs2 ok641

LETHAL

    

-

unc-129; etIs2

91.7

 

2.0

6.3

 

204

unc-129; etIs2 ok641

74.1

8.6

8.2

9.1

 

220

  1. Notes
  2. wt: normal
  3. Misplac: M2 cell body mispositioned into the metacorpus
  4. Ipsil: ipsilateral outgrowth
  5. Trunc: truncated distal end
  6. Contra: contralateral outgrowth
  7. Post: posterior outgrowth
  8. Other: Contralateral outgrowths in the case of sax-3;etIs2, unc-6; etIs2 ok641 and unc-40; etIs2. Ectopic dorsal branch, posterior branch, misplaced cell into isthmus, growth posterior from metacorpus back into isthmus in the case of mig-14; etIs2 and mig-14;ok641 etIs2.