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Figure 6 | BMC Developmental Biology

Figure 6

From: Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow

Figure 6

A model explaining the control of Ablim1 expression in the node and the left LPM. (a) Nodal flow and Pkd2 activate both the Nodal, Pitx2 pathway and a second pathway "X". Both pathways in turn activate Ablim1 in the left LPM. (b) In the node, the initial change of Ablim1 expression, from low level pan-nodal to a perinodal ring, require nodal flow and Pkd2 activity. Subsequent L-R asymmetry of perinodal ring expression may be controlled by nodal flow and its interaction with the remodelling of the node during development.

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