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Figure 4 | BMC Developmental Biology

Figure 4

From: Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow

Figure 4

A novel asymmetric expression pattern for Ablim1 at the node. Temporal analysis of Ablim1 expression in the node, using the Ex2-6 probe. Initial expression across the node at the Early Headfold stage (a), becomes modified by the mid headfold stage (b) and by late headfold stages (c) describes a peri-nodal ring that shows stronger right than left-sided expression. By early somite stages (d) peri-nodal expression has been lost from the anteriormost left side of the node as well as being evident in the midline. (e) By 4 somites expression is restricted to the right side of the node. (f) At 5 somites node expression is restricted to the anteriormost right side and becomes restricted to the midline by 7 somites (g). (h) By 8 somites expression was absent form the node. (i) A section of a late headfold embryo (as in panel c) showing that expression in the node is restricted to the ventral layer of the node. Left (L) and Right (R) are as indicated on the panels.

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