Figure 4
From: Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome
Placental glycogen cells and labyrinthine architecture of the DelTel7/IC2KO placentae at E14.5. A) Trophoblast glycogen cells are highlighted by periodic acid Schiff (PAS) staining of DelTel7/IC2KO placentae (n = 4) compared with wild type (n = 4). Scale bar: 1 mm. B) Detection of Pcdh12, a glycogen cell marker, by ISH on DelTel7/IC2KO placentae (n = 4) compared with wild type (n = 4). Scale bar = 0.25 mm. C) Extraembryonic mesoderm of the labyrinth layer detected by laminin IHC on DelTel7/IC2KO placentae (n = 4) compared with wild type (n = 4). Scale bar = 0.25 mm. D) Peg1/Mest ISH of DelTel7/IC2KO placentae (n = 4) compared with wild type (n = 4). Scale bar = 0.25 mm. GCs: glycogen cells; sp: spongiotrophoblast; lab: labyrinth.