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Figure 9 | BMC Developmental Biology

Figure 9

From: Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas

Figure 9

Postnatal islet cells derive from embryonic Muc1+ progenitors. Muc1IC2/IC2; Rosa26EYFP/+ mice received tamoxifen in utero (5 mg to pregnant dam at E14.5), and were analyzed at P21 by immunofluorescence for EYFP lineage label (green), insulin (A-C, red) and glucagon (D-F, red). After inducing the Muc1 lineage at E14.5 and chasing offspring until P21, EYFP labeling (white arrowheads) is detected among both insulin+ β-cells (2.2 +/- 0.4%) and glucagon+ α-cells (2.1 +/- 0.2%). Scale bar: 50 μm.

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