Figure 10

Electron micrographs of day 45 seminiferous tubules reveal abnormal phagocytic membranous wheels in Ehd1^-/- mice. (A) In WT mice, step 8 round spermatids were found in (B) early stage VIII seminiferous tubules that contained elongated spermatids in the process of spermiation near the lumen with tails apparent after spermiation; box enlarged in (C). (C) A WT elongated spermatid prior to spermiation maintains its ectoplasmic specializations (ES). (D) In Ehd1^-/- mice, step 8 round spermatids were found in (E) late stage VIII seminiferous tubules that contained phagocytic membranous wheels engulfing elongated spermatids, their acrosomes and sperm tails; box enlarged in (F).