Figure 7

An allelic series of Notch1 mutants. Based on data reported herein and from the literature, the relative signaling strength of Notch1 mutant alleles in various combinations with wild type or other Notch1 mutant alleles is represented as discussed in the Discussion. The consequences with respect to time of death of embryos with severe Notch1 signaling defects, or more subtle defects in T cell, CNS or cardiac development are noted.