Skip to main content
Figure 4 | BMC Developmental Biology

Figure 4

From: Effects of varying Notch1 signal strength on embryogenesis and vasculogenesis in compound mutant heterozygotes

Figure 4

Defects in vascular remodeling in Notch112f/lbdE9.5 embryos. All whole mount embryos were stained with Ab to Pecam1. (A-D) Morphogenesis of the main trunk of the anterior cardinal vein (arrow) in Notch112f/lbdand Notch1lbd/lbdmutant embryos is defective compared to Notch112f/12fand control Notch1+/12fembryos. (E-H) Vascular remodeling in brain in Notch1+/12fand Notch112f/12fis similar but is defective in Notch112f/lbdand severely defective in Notch1lbd/lbdembryos. (I-L) Vascular remodeling in heart is defective in Notch112f/lbdand more severely affected in Notch1lbd/lbdembryos. (M-P) Intersomitic vessels (arrows) were well-organized in Notch1+/12fand Notch112f/12fembryos but were mildly disorganized in Notch112f/lbdand essentially absent from Notch1lbd/lbdembryos. The number of embryos examined was 3 - 4 of each genotype.

Back to article page