Figure 3

Embryogenesis in Notch1^12f/lbdembryos. (A-D) Vascularization of yolk sac in Notch1^+/12f, Notch1^12f/12f, Notch1^12f/lbdand Notchl^lbd/lbdembryos at E9.5. Large vitelline blood vessels were present in Notch1^+/12f and Notch1^12f/12fyolk sacs, but absent in the Notch1^12f/lbdand Notch1^lbd/lbdmutants. (E-H) Morphology of embryos at E9.5. Notch1^12f/12fare similiar to Notch1^+/12f, Notch1^12f/lbdare markedly underdeveloped, and Notch1^lbd/lbdare severely underdeveloped. (I-L) Notch1^12f/lbdembryos from E10.5-E12.5. White arrows show hemorrhaging in E10.5 and E11.5 embryos; most E12.5 embryos were resorbing. The number of embryos examined at each stage is given in Table 1.