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Table 2 Suture closure in Apert syndrome mice

From: Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+P253R mice

  Fusion
Sutures +/P253R
(n = 10)
+/+ littermate
(n = 7)
+/S252W
(n = 8)
+/+ littermate
(n = 12)
  closed/total* closed/total closed/total patent/closed
Coronal (bi- or unicoronal) 9/10 0/7 7/8 0/12
Zygomatic-maxillary 10/10 0/7 7/8 0/12
Maxilla-premaxillary 10/10 0/7 8/8 0/12
Inter-premaxillary 0/10 7/7 1/8 11/12
Inter-palatine 0/10 2/7 0/8 3/12
Maxillary-palatine 1/10 4/7 7/8 5/12
  1. * The observation of "closed" varies from simple bridging across the suture to complete closure. Closure can be unilateral or bilateral. Because these are P0 mice, it should be recognized that suture closure is a dynamic process and will vary given the age of the mice observed.