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Table 3 Effects of p53 on CP-induced limb phenotype (dose of 20 mg/kg)

From: Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: correlation with embryonic p53 genotype and limb phenotype

Tested embryonic structure p53 genotype Number of tested embryos Number of embryos exhibiting:
    Digit anomalies Limb reduction anomalies
Forelimbs +/+ and +/- 64 24(37.5%) 0
  -/- 28 0* 0
Hindlimbs +/+ and +/- 64 62 (96.9%) 24 (37.5%)
  -/- 28 4 (14.3%)* 0*
  1. Differences between p53 positive and p53 negative embryos are statistically significant (the Fisher exact test, p < 0.05).