Doses of cyclophosphamide | Â | 12.5 mg/kg | CP 20 mg/kg | CP 40 mg/kg |
---|---|---|---|---|
Number of tested embryos | Â | 80 | 92 | 61 |
Type of anomalies |  | Fetuses with malformed limbs§ | ||
 | Forelimbs | 6 (7.5%) | 24 (26.1%) | 59 (96.7%) |
 |  | 17.7 ± 3.5a | 32.4 ± 3.1b | 73.0 ± 0.5 c |
Digit anomalies1 arcsine, mean ± SE |  |  |  |  |
 | Hindlimbs | 23(28.8%) | 66 (71.7%) | 61 (100%) |
 |  | 32.5 ± 3.5a* | 55.9 ± 3.8b* | 78.9 ± 0.3c |
 | Forelimbs | 0 | 0 | 0 |
 |  | 9.9 ± 0.3 | 10.7 ± 0.4 | 11.0 ± 0.3 |
Limb reduction anomalies, arcsine, mean ± SE |  |  |  |  |
 | Hindlimbs | 0 | 24 (26.1%) | 61 (100%) |
 |  | 9.9 ± 0.3a | 32.4 ± 3.1b* | 78.9 ± 0.3c* |