A, Ontogenetic series of μCT scans showing the range of shape and size variation from E9.5-12. B, Regression of total shape variation on tail-somite stage (TS) and wireframe deformation showing the corresponding shape trajectory. C, Morphing of a μCT surface render along the same shape trajectory (size constant). D, Comparison of the two groups at three standardized stages. Crf4 mice have a mutation on a C57BL/6J background that produces a complex set of craniofacial changes .