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Figure 1 | BMC Developmental Biology

Figure 1

From: Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation

Figure 1

Impaired clearance of apoptotic mammary epithelial cells during involution in MerTK-deficient mice. A. H&E-stained sections of mammary glands harvested at lactation day 10 from WT or mertk-/- mammary glands. B-C. H&E-stained sections of mammary glands harvested at 3 dpfw (B) and 7 dpfw (C) from WT and mertk-/- mammary glands. Boxed areas are shown in higher magnification, where indicated in B indicate AC accumulation in the ductal lumen and in regressing alveolar structures. Arrows in C indicate apoptotic cells surrounding live cells in a rosette pattern. D Immunohistochemical detection of TUNEL-positive cells at 7 dpfw. Values shown in D (left panel) are the average percentage of total nuclei that are TUNEL-positive. N = 5 (X 3 random 400X fields per sample). P = 0.002, Student's unpaired T-test.

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