Figure 7
Loss of cortical hem and plexus, and expanded roof plate in Gli1/2 -/- brains differ from dorsal midline defects resulting from FGF inhibition. RNA in situ hybridization analysis of E12.5 wild type littermate control (A-C), Gli 1/2 -/- double knock-out (D-F), and FGF antagonist-injected (G-I) telencephalon. Wnt3a: A, D, G, rTTR: B, E, H, Lhx5: C, F, I. n = 2. Scale bar in A represents 200 μm and all panels in this figure are photographed at the same magnification (5×).