Figure 2
From: β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis
Stimulation of β-catenin interferes with cell proliferation in the developing suture mesenchyme. (A, B) Expression of sβ-cat increases the number of Ki67 positive cells suggesting that proliferation of skeletal precursors is enhanced in the metopic suture at one week after birth. The numbers of cyclin D1 (CycD1; C, D) and Cdk4 (E, F) positive cells also increase drastically in the mutants. The broken lines define the suture region. (G) Graph indicates the average percentage of the positive stained cells in the controls and mutants (mean + SEM). Scale bars, 50 μm (A-F).