Figure 7
Spleen morphology of Lc3 synthase-knockout mice. Mouse spleens from three different genome types of similar age were sectioned and stained. The wild-type controls included a littermate (panel a) and a mouse from a non-knockout colony (panel b). White pulp is indicated by a white arrow in panel a, and the green arrow indicates red pulp. A germinal center is indicated by a white arrow in panel b. In both Wt/KO and KO/KO genotypes (panels c and d) tissue, the arrowhead indicates fused white pulp. The germinal center in the KO/KO mouse spleen (panel d) is not clearly defined.