Figure 6

Alopecia and obesity in Lc3 synthase knockout mice. A. Incidence of alopecia and obesity. A weight of >40 g in a male was counted as obesity. B. Alopecia. Fur loss was seen in all three genome types (wild-type data not shown) and could occur anywhere on the mouse's body. The arrowhead indicates where the fur loss caused difficulty in extension of hind limbs, and the arrows show fur growing again with less density. C. Late-stage obesity. Mice were weighed periodically. In panel b, the 24.6-g control with a genotype +/- was from the same litter as the obese mouse.