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Figure 1 | BMC Developmental Biology

Figure 1

From: Multiple phenotypic changes in mice after knockout of the B3gnt5gene, encoding Lc3 synthase—a key enzyme in lacto-neolacto ganglioside synthesis

Figure 1

Lc3 synthase within the gangliosynthesis pathways. The X in the lacto-neolacto series biosynthesis pathway indicates a block due to disruption of the Lc3 synthase gene, B3gnt5. Six ganglioside synthesis pathways are shown: globo, gala, neolacto, lacto, a, and b. The molecules 3'-LM1, 3'-isoLM1, and 3',6'-isoLD1 are shown within the lacto-neolacto pathways. Gangliosides GM1 and GD1a are shown in the a-series pathway and ganglioside GD1b in the b-series pathway. Ganglioside nomenclature according to Svennerholm [44].

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BMC Developmental Biology

ISSN: 1471-213X

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