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Table 1 Cellular distribution of Notch modifiers selected by the complimentary analysis methods.

From: Modifiers of notch transcriptional activity identified by genome-wide RNAi

Analysis Method

Total

Extracellular

Membrane

Cytosolic

Nuclear

Unknown

NΔecn > m3-luc/con-luc (Activators)

153

8 (5.2%)

2 (2.6%)

28 (18.3%)

40 (26.1%)

73 (47.7%)

NΔecn > m3-luc/con-luc (Repressors)

130

0

5 (3.8%)

17 (13.1%)

27 (20.8%)

81 (62.3%)

NΔecn > m3-luc/m3-luc (Activators)

75

0

1 (1.3%)

12 (16.0%)

28 (37.3%)

34 (45.3%)

NΔecn > m3-luc/m3-luc (Repressors)

74

0

2 (2.7%)

13 (17.6%)

5 (20.3%)

44 (59.5%)

Total (discounting duplicates)

399

2%

3%

16%

26%

53%

  1. The majority of the proteins are of unknown cellular localization and/or function. Of the annotated proteins, most are predicted to reside in the nucleus, followed by cytosolic proteins with a small percentage found in the plasma membrane and extracellular matrix.