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Table 1 Cellular distribution of Notch modifiers selected by the complimentary analysis methods.

From: Modifiers of notch transcriptional activity identified by genome-wide RNAi

Analysis Method Total Extracellular Membrane Cytosolic Nuclear Unknown
NΔecn > m3-luc/con-luc (Activators) 153 8 (5.2%) 2 (2.6%) 28 (18.3%) 40 (26.1%) 73 (47.7%)
NΔecn > m3-luc/con-luc (Repressors) 130 0 5 (3.8%) 17 (13.1%) 27 (20.8%) 81 (62.3%)
NΔecn > m3-luc/m3-luc (Activators) 75 0 1 (1.3%) 12 (16.0%) 28 (37.3%) 34 (45.3%)
NΔecn > m3-luc/m3-luc (Repressors) 74 0 2 (2.7%) 13 (17.6%) 5 (20.3%) 44 (59.5%)
Total (discounting duplicates) 399 2% 3% 16% 26% 53%
  1. The majority of the proteins are of unknown cellular localization and/or function. Of the annotated proteins, most are predicted to reside in the nucleus, followed by cytosolic proteins with a small percentage found in the plasma membrane and extracellular matrix.