TY - JOUR AU - Wong, Loksum AU - Weadick, Cameron J. AU - Kuo, Claire AU - Chang, Belinda SW AU - Tropepe, Vincent PY - 2010 DA - 2010/09/22 TI - Duplicate dmbx1genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development JO - BMC Developmental Biology SP - 100 VL - 10 IS - 1 AB - The Dmbx1 gene is important for the development of the midbrain and hindbrain, and mouse gene targeting experiments reveal that this gene is required for mediating postnatal and adult feeding behaviours. A single Dmbx1 gene exists in terrestrial vertebrate genomes, while teleost genomes have at least two paralogs. We compared the loss of function of the zebrafish dmbx1a and dmbx1b genes in order to gain insight into the molecular mechanism by which dmbx1 regulates neurogenesis, and to begin to understand why these duplicate genes have been retained in the zebrafish genome. SN - 1471-213X UR - https://doi.org/10.1186/1471-213X-10-100 DO - 10.1186/1471-213X-10-100 ID - Wong2010 ER -