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  1. Research article

    Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis

    Birt-Hogg-Dubé syndrome (BHD) is a dominantly inherited familial cancer syndrome characterised by the development of benign skin fibrofolliculomas, multiple lung and kidney cysts, spontaneous pneumothorax and ...

    Emma J. Kenyon, Monique N. H. Luijten, Harmeet Gill, Nan Li, Matthew Rawlings, James C. Bull, Yavor Hadzhiev, Maurice A. M. van Steensel, Eamonn Maher and Ferenc Mueller

    BMC Developmental Biology 2016 16:23

    Published on: 8 July 2016

  2. Methodology article

    Light-sheet microscopy for everyone? Experience of building an OpenSPIM to study flatworm development

    Selective plane illumination microscopy (SPIM a type of light-sheet microscopy) involves focusing a thin sheet of laser light through a specimen at right angles to the objective lens. As only the thin section ...

    Johannes Girstmair, Anne Zakrzewski, François Lapraz, Mette Handberg-Thorsager, Pavel Tomancak, Peter Gabriel Pitrone, Fraser Simpson and Maximilian J. Telford

    BMC Developmental Biology 2016 16:22

    Published on: 30 June 2016

  3. Research article

    MR microscopy of the human fetal upper extremity – a proof-of-principle study

    Current knowledge of the human fetal and embryonic development relies on early descriptive studies of humans and from experimental studies of laboratory animals and embryos. Taking the upper extremity as an ex...

    Inga Langner, Thomas Stahnke, Oliver Stachs, Tobias Lindner, Jens-Peter Kühn, Simon Kim, Andreas Wree and Soenke Langner

    BMC Developmental Biology 2016 16:21

    Published on: 18 June 2016

  4. Research article

    Adhesive organ regeneration in Macrostomum lignano

    Flatworms possess pluripotent stem cells that can give rise to all cell types, which allows them to restore lost body parts after injury or amputation. This makes flatworms excellent model systems for studying...

    Birgit Lengerer, Elise Hennebert, Patrick Flammang, Willi Salvenmoser and Peter Ladurner

    BMC Developmental Biology 2016 16:20

    Published on: 2 June 2016

  5. Research article

    Late stage definitive endodermal differentiation can be defined by Daf1 expression

    Definitive endoderm (DE) gives rise to the respiratory apparatus and digestive tract. Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE marker, Decay accelerating factor 1(Daf1...

    Soichiro Ogaki, Hisayoshi Omori, Mayu Morooka, Nobuaki Shiraki, Seiichi Ishida and Shoen Kume

    BMC Developmental Biology 2016 16:19

    Published on: 31 May 2016

  6. Research article

    A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis

    Insect metamorphosis relies on temporal and spatial cues that are precisely controlled. Previous studies in Drosophila have shown that untimely activation of genes that are essential to metamorphosis results in g...

    Kimberly Regna, Peri T. Kurshan, Benjamin N. Harwood, Adam M. Jenkins, Chao-Qiang Lai, Marc A.T. Muskavitch, Alan S. Kopin and Isabelle Draper

    BMC Developmental Biology 2016 16:15

    Published on: 16 May 2016

  7. Research article

    β-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis

    The pituitary gland is a highly vascularized tissue that requires coordinated interactions between the neural ectoderm, oral ectoderm, and head mesenchyme during development for proper physiological function. ...

    Shannon W. Davis, Amanda H. Mortensen, Jessica L. Keisler, Amanda L. Zacharias, Philip J. Gage, Ken-ichi Yamamura and Sally A. Camper

    BMC Developmental Biology 2016 16:16

    Published on: 16 May 2016

  8. Research article

    Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis

    Wnt5a and Mrfzb1 genes are involved in the regulation of tooth size, and their expression levels are similar to that of Bmp7 during morphogenesis, including during the cap and early be...

    Kazuyuki Saito, Katsu Takahashi, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Masaharu Motokawa, Harold C. Slavkin and Kazuhisa Bessho

    BMC Developmental Biology 2016 16:14

    Published on: 13 May 2016

  9. Research article

    Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development

    During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expres...

    Jimena Monzón-Sandoval, Atahualpa Castillo-Morales, Araxi O. Urrutia and Humberto Gutierrez

    BMC Developmental Biology 2016 16:13

    Published on: 12 May 2016

  10. Research article

    Co-culture with neonatal cardiomyocytes enhances the proliferation of iPSC-derived cardiomyocytes via FAK/JNK signaling

    We previously reported that the pluripotent stem cells can differentiate into cardiomyocytes (CMs) by co-culture with neonatal CMs (NCMs) in vitro. However, the involving mechanism is not clear.

    Dongbo Ou, Qi Wang, Yanjin Huang, Di Zeng, Ting Wei, Lu Ding, Xiaoli Li, Qiangsun Zheng and Yan Jin

    BMC Developmental Biology 2016 16:11

    Published on: 4 May 2016

  11. Research article

    Live imaging of muscle histolysis in Drosophila metamorphosis

    The contribution of programmed cell death (PCD) to muscle wasting disorders remains a matter of debate. Drosophila melanogaster metamorphosis offers the opportunity to study muscle cell death in the context of de...

    Yadav Kuleesha, Wee Choo Puah and Martin Wasser

    BMC Developmental Biology 2016 16:12

    Published on: 4 May 2016

  12. Research article

    Early development of the root-knot nematode Meloidogyne incognita

    Detailed descriptions of the early development of parasitic nematodes are seldom available. The embryonic development of the plant-parasitic nematode Meloidogyne incognita was studied, focusing on the early event...

    Alejandro Calderón-Urrea, Bartel Vanholme, Sandra Vangestel, Saben M. Kane, Abdellatif Bahaji, Khavong Pha, Miguel Garcia, Alyssa Snider and Godelieve Gheysen

    BMC Developmental Biology 2016 16:10

    Published on: 28 April 2016

  13. Research article

    The combined effect of PDX1, epidermal growth factor and poly-L-ornithine on human amnion epithelial cells’ differentiation

    It has been suggested that the ectopic expression of PDX1, a dominant pancreatic transcription factor, plays a critical role in the developmental programming of the pancreas even from cells of unrelated tissue...

    Shruti Balaji, Yu Zhou, Anasuya Ganguly, Emmanuel C. Opara and Shay Soker

    BMC Developmental Biology 2016 16:8

    Published on: 12 April 2016

  14. Research article

    Apontic regulates somatic stem cell numbers in Drosophila testes

    Microenvironments called niches maintain resident stem cell populations by balancing self-renewal with differentiation, but the genetic regulation of this process is unclear. The niche of the Drosophila testis...

    Amanda J. Monahan and Michelle Starz-Gaiano

    BMC Developmental Biology 2016 16:5

    Published on: 18 March 2016

  15. Research article

    Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway

    The Hedgehog (Hh) signaling pathway, acting through three homologous transcription factors (GLI1, GLI2, GLI3) in vertebrates, plays multiple roles in embryonic organ development and adult tissue homeostasis. A...

    Katherine Gurdziel, Kyle R. Vogt, Gary Schneider, Neil Richards and Deborah L. Gumucio

    BMC Developmental Biology 2016 16:4

    Published on: 24 February 2016

  16. Research article

    Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development

    Bone morphogenetic proteins regulate multiple processes in embryonic development, including early dorso-ventral patterning and neural crest development. BMPs activate heteromeric receptor complexes consisting ...

    Carolin Schille, Jens Heller and Alexandra Schambony

    BMC Developmental Biology 2016 16:1

    Published on: 19 January 2016

  17. Methodology article

    Revisiting in vivo staining with alizarin red S - a valuable approach to analyse zebrafish skeletal mineralization during development and regeneration

    The correct evaluation of mineralization is fundamental for the study of skeletal development, maintenance, and regeneration. Current methods to visualize mineralized tissue in zebrafish rely on: 1) fixed spec...

    A. Bensimon-Brito, J. Cardeira, G. Dionísio, A. Huysseune, M. L. Cancela and P. E. Witten

    BMC Developmental Biology 2016 16:2

    Published on: 19 January 2016

  18. Methodology article

    A co-culture assay of embryonic zebrafish hearts to assess migration of epicardial cells in vitro

    The vertebrate heart consists of three cell layers: the innermost endothelium, the contractile myocardium and the outermost epicardium. The epicardium is vital for heart development and function, and forms fro...

    Monica S. Yue, Jessica S. Plavicki, Xin-yi Li, Richard E. Peterson and Warren Heideman

    BMC Developmental Biology 2015 15:50

    Published on: 29 December 2015

  19. Research article

    Identification of differential microRNA expression during tooth morphogenesis in the heterodont dentition of miniature pigs, SusScrofa

    It has been found that microRNAs (miRNAs) play important roles in the regulation of tooth development, and most likely increase the complexity of the genetic network, thus lead to greater complexity of teeth. ...

    Ang Li, Ye Li, Tieli Song, Fu Wang, Dayong Liu, Zhipeng Fan, San Cheng, Chunmei Zhang, Jinsong Wang, Junqi He and Songlin Wang

    BMC Developmental Biology 2015 15:51

    Published on: 29 December 2015

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