Early development

Section edited by Anna-Katerina Hadjantonakis

This section considers studies in all aspects of the early development of organisms, including embryonic and somite development.

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  1. Research article

    Mice lacking the conserved transcription factor Grainyhead-like 3 (Grhl3) display increased apposition of the frontal and parietal bones during embryonic development

    Increased apposition of the frontal and parietal bones of the skull during embryogenesis may be a risk factor for the subsequent development of premature skull fusion, or craniosynostosis. Human craniosynostos...

    Stephen J. Goldie, Benedicta D. Arhatari, Peter Anderson, Alana Auden, Darren D. Partridge, Stephen M. Jane and Sebastian Dworkin

    BMC Developmental Biology 2016 16:37

    Published on: 18 October 2016

  2. Research article

    Lack of effects of ooplasm transfer on early development of interspecies somatic cell nuclear transfer bison embryos

    Successful development of iSCNT (interspecies somatic cell nuclear transfer) embryos depends on complex interactions between ooplasmic and nuclear components, which can be compromised by genetic divergence. Tr...

    L. Antonio González-Grajales, Laura A. Favetta, W. Allan King and Gabriela F. Mastromonaco

    BMC Developmental Biology 2016 16:36

    Published on: 13 October 2016

  3. Research article

    The E3 ubiquitin ligase Hace1 is required for early embryonic development in Xenopus laevis

    HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) regulates a wide variety of cellular processes. It has been shown that one of the targets of HACE1 is the GTP-bound form of the s...

    Akira Iimura, Fuhito Yamazaki, Toshiyasu Suzuki, Tatsuya Endo, Eisuke Nishida and Morioh Kusakabe

    BMC Developmental Biology 2016 16:31

    Published on: 21 September 2016

  4. Research article

    Late stage definitive endodermal differentiation can be defined by Daf1 expression

    Definitive endoderm (DE) gives rise to the respiratory apparatus and digestive tract. Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE marker, Decay accelerating factor 1(Daf1...

    Soichiro Ogaki, Hisayoshi Omori, Mayu Morooka, Nobuaki Shiraki, Seiichi Ishida and Shoen Kume

    BMC Developmental Biology 2016 16:19

    Published on: 31 May 2016

  5. Research article

    Early development of the root-knot nematode Meloidogyne incognita

    Detailed descriptions of the early development of parasitic nematodes are seldom available. The embryonic development of the plant-parasitic nematode Meloidogyne incognita was studied, focusing on the early event...

    Alejandro Calderón-Urrea, Bartel Vanholme, Sandra Vangestel, Saben M. Kane, Abdellatif Bahaji, Khavong Pha, Miguel Garcia, Alyssa Snider and Godelieve Gheysen

    BMC Developmental Biology 2016 16:10

    Published on: 28 April 2016

  6. Research article

    Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development

    Bone morphogenetic proteins regulate multiple processes in embryonic development, including early dorso-ventral patterning and neural crest development. BMPs activate heteromeric receptor complexes consisting ...

    Carolin Schille, Jens Heller and Alexandra Schambony

    BMC Developmental Biology 2016 16:1

    Published on: 19 January 2016

  7. Methodology article

    3D structured illumination microscopy of mammalian embryos and spermatozoa

    Super-resolution fluorescence microscopy performed via 3D structured illumination microscopy (3D-SIM) is well established on flat, adherent cells. However, blastomeres of mammalian embryos are non-adherent, ro...

    Jens Popken, Maik Dahlhoff, Tuna Guengoer, Eckhard Wolf and Valeri Zakhartchenko

    BMC Developmental Biology 2015 15:46

    Published on: 26 November 2015

  8. Research article

    The developmental basis of mesenchymal stem/stromal cells (MSCs)

    Mesenchymal Stem/Stromal Cells (MSCs) define a population of progenitor cells capable of giving rises to at least three mesodermal lineages in vitro, the chondrocytes, osteoblasts and adipocytes. The validity ...

    Guojun Sheng

    BMC Developmental Biology 2015 15:44

    Published on: 20 November 2015

  9. Methodology article

    A loss-of-function and H2B-Venus transcriptional reporter allele for Gata6 in mice

    The GATA-binding factor 6 (Gata6) gene encodes a zinc finger transcription factor that often functions as a key regulator of lineage specification during development. It is the earliest known marker of the primit...

    Laina Freyer, Christian Schröter, Néstor Saiz, Nadine Schrode, Sonja Nowotschin, Alfonso Martinez-Arias and Anna-Katerina Hadjantonakis

    BMC Developmental Biology 2015 15:38

    Published on: 24 October 2015

  10. Research article

    Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells

    Primitive endoderm is a cell lineage segregated from the epiblast in the blastocyst and gives rise to parietal and visceral endoderm. Sox7 is a member of the SoxF gene family that is specifically expressed in pri...

    Masaki Kinoshita, Daisuke Shimosato, Mariko Yamane and Hitoshi Niwa

    BMC Developmental Biology 2015 15:37

    Published on: 16 October 2015

  11. Research article

    Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation

    Pluripotent cells are present in early embryos until the levels of the pluripotency regulator Oct4 drop at the beginning of somitogenesis. Elevating Oct4 levels in explanted post-pluripotent cells in vitro res...

    Constantinos Economou, Anestis Tsakiridis, Filip J. Wymeersch, Sabrina Gordon-Keylock, Robert E Dewhurst, Dawn Fisher, Alexander Medvinsky, Andrew JH Smith and Valerie Wilson

    BMC Developmental Biology 2015 15:35

    Published on: 9 October 2015

  12. Research article

    Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line

    Chloride Intracellular Channel 4 (CLIC4) is one of seven members in the closely related CLIC protein family. CLIC4 is involved in multiple cellular processes including apoptosis, cellular differentiation, infl...

    VC Padmakumar, Katelyn E Masiuk, Dror Luger, Christina Lee, Vincenzo Coppola, Lino Tessarollo, Shelley B Hoover, Irina Karavanova, Andres Buonanno, R Mark Simpson and Stuart H Yuspa

    BMC Developmental Biology 2014 14:24

    Published on: 28 May 2014

  13. Research article

    Construction of a cDNA library for miniature pig mandibular deciduous molars

    The miniature pig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resembles that of humans. However, little information is available on the proc...

    Tieli Song, Tingting Wu, Fulan Wei, Ang Li, Fu Wang, Yilin Xie, Dayong Liu, Zhipeng Fan, Xuejiu Wang, Shan Cheng, Chunmei Zhang, Junqi He and Songlin Wang

    BMC Developmental Biology 2014 14:16

    Published on: 21 April 2014

  14. Research article

    Craniofacial divergence by distinct prenatal growth patterns in Fgfr2 mutant mice

    Differences in cranial morphology arise due to changes in fundamental cell processes like migration, proliferation, differentiation and cell death driven by genetic programs. Signaling between fibroblast growt...

    Susan M Motch Perrine, Theodore M Cole, Neus Martínez-Abadías, Kristina Aldridge, Ethylin Wang Jabs and Joan T Richtsmeier

    BMC Developmental Biology 2014 14:8

    Published on: 28 February 2014

  15. Research article

    Primary culture of avian embryonic heart forming region cells to study the regulation of vertebrate early heart morphogenesis by vitamin A

    Important knowledge about the role of vitamin A in vertebrate heart development has been obtained using the vitamin A-deficient avian in ovo model which enables the in vivo examination of very early stages of ver...

    Inese Cakstina, Una Riekstina, Martins Boroduskis, Ilva Nakurte, Janis Ancans, Maija H Zile and Indrikis Muiznieks

    BMC Developmental Biology 2014 14:10

    Published on: 19 February 2014

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